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Nagarathna, P. K. M.
- Anti Diabetic Activity of Sida cordifolia Linn of Nilgiris Root on Alloxan Induced Diabetic Rats
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1 Karnataka College of Pharmacy, No.33/2, Thirumenahalli, Hegde Nagar Main Road, Yelahanka Hobli, Jakkur Post Bangalore-64, IN
1 Karnataka College of Pharmacy, No.33/2, Thirumenahalli, Hegde Nagar Main Road, Yelahanka Hobli, Jakkur Post Bangalore-64, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 1, No 3 (2009), Pagination: 125-127Abstract
The aim of the present study was to screen the antidiabetic potential of the ischolar_main of Sida cordifolia linn. In the present study, ischolar_main of Sida cordifolia linn was screened for antidiabetic activity. Root powder of Sida cordifolia was subjected to hot continuous extraction (soxhlet) with various solvents like petroleum ether, (40-600° C), chloroform, butanol, butanone and alcohol. Aqueous extract was prepared by cold maceration. After preliminary phytochemical investigation, all the extracts were evaluated for anti diabetic activity after single dose (acute study) and after prolonged treatment (chronic study in alloxan induced diabetic albino rats. Al thel extracts were given orally at a dose of 250mg/Kg b.w. Glibenclamide was used as standard drug (10mg/Kg b.w. P.o). Alcohol butonal, Chloroform, aqueous and butanone showed significant antidiabetic activity in acute as well as prolonged treatment compared to control. Petrolium ether extract did not show significant anti diabetic activity on prolonged treatment. Among all the extracts, alcoholic extracts had more significantly reduced the blood glucose level after single dose and nearly equal to standard glibenclamide after prolonged treatment.Keywords
Sida cordifolia, Anti Diabetic, Glibenclamide, Alloxan.References
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- Diuretic Activity of Pongamia pinnata Linn. Leaf Extracts in Rats
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Authors
Affiliations
1 Karnataka College of Pharmacy, Bangalore, IN
2 Department of Pharmacology, Karnataka College of Pharmacy, #33\2, Thirumenahalli, Hegde Nagar Main Road, Yelahanka Hobli, Jakkur Post, Bangalore-560064, IN
1 Karnataka College of Pharmacy, Bangalore, IN
2 Department of Pharmacology, Karnataka College of Pharmacy, #33\2, Thirumenahalli, Hegde Nagar Main Road, Yelahanka Hobli, Jakkur Post, Bangalore-560064, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 1, No 3 (2009), Pagination: 185-187Abstract
Pongamia pinnata Linn were evaluated by determination of urine volume, electrolyte concentration and diuretic potency in male albino rats. Different concentrations of petroleum ether, and methanol extract (250 mg/kg, 500mg/kg) were orally administered to hydrated rats and their urine out put was immediately measured after 5 h of treatment. Furosamide (10 mg/kg) was used as reference drug while normal saline (0.9%) solution was used as control. The petroleum ether extract exhibited dose dependent diuretic property. The onset of diuretic action was extremely prompt (within 1h) and lasted through out the studied period (upto 5h). The ethanol and petroleum ether extracts caused marked increase in Na+., K+ and Cl- level. The result of this experiment suggests that Pongamia pinnata Linn leaves extracts possessed significant diuretic activity in rats.Keywords
Diuretic Activity, Pongamia pinnata Linn, Ethanol Petroleum Ether Extracts.- Emerging Role of GABA Receptor:A Review
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Authors
Affiliations
1 Department of Pharmacology, Karnataka College of Pharmacy, Bangalore, IN
1 Department of Pharmacology, Karnataka College of Pharmacy, Bangalore, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 7 (2019), Pagination: 3197-3205Abstract
GABAA receptor subunit genes GABRB3, GABRA5, and GABRG3 located on chromosome 15q11-q13 have been implicated in the etiology of autistic spectrum disorders (ASD). This study intended to investigate the possible role of single-nucleotide polymorphisms (SNPs) present in GABRB3 (rs2081648 and rs1426217), GABRA5 (rs35586628), and GABRG3 (rs208129) genes in ASD susceptibility and symptom-based and developmental phenotypes of ASD in Chinese Han children and adolescents. Anti-epileptic drugs (AEDs) continue to be the mainstay of epilepsy treatment, but the benefits of seizure control need to be weighed carefully against possible adverse effects, which can include behavioral problems and psychiatric disorders. In this paper, the associations between AEDs and psychosis, depression and behavioral changes are reviewed. Depression seems to be linked with AEDs potentiating GABAergic neurotransmission in patients with limbic system abnormalities such as hippocampal sclerosis. By rapidly modulating neuronal excitability, neurosteroids regulate physiological processes, such as responses to stress and development. Excessive stress affects their biosynthesis and causes an imbalance in cognition and emotions. The progesterone derivative, allopregnanolone (Allo) enhances extra synaptic and postsynaptic inhibition by directly binding at GABAA receptors, and thus, positively and allosterically modulates the function of GABA. Stress-induced down-regulation of neurosteroid biosynthesis and changes in GABAA receptor subunit expression offer a putative biomarker axis to develop new PTSD treatments. The advantage of stimulating Allo biosynthesis relies on the variety of neurosteroidogenic receptors to be targeted, including TSPO and endocannabinoid receptors. Furthermore, stress favours a GABAA receptor subunit composition with higher sensitivity for Allo.Keywords
GABAA, GABRB3, GABRA5, Neurosteroids, Allo.References
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